Galloylpaeoniflorin

SKU: orb1297575

Description

Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) is a bioactive small molecule with cytoprotective properties against reactive oxygen species (ROS)-induced oxidative stress. It functions as an inhibitor of NF-κB activation and DNA cleavage, making it a compound of interest for research in cellular stress response, inflammation, and apoptosis in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 122965-41-7
• MW: 632.57
• Purity: 97.10% (May vary between batches)
• Formula: C₃₀H₃₂O₁₅
• SMILES: [H][C@@]12C[C@@]3(O[C@]4([H])O[C@H](COC(=O)c5cc(O)c(O)c(O)c5)[C@@H](O)[C@H](O)[C@H]4O)[C@]1(COC(=O)c1ccccc1)[C@@]1([H])O[C@]2(O)C[C@]3(C)O1
• Target: NF-κB|||Androgen Receptor|||ROS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.16 mM);DMSO:50 mg/mL (79.04 mM)

Bioactivity

• In Vitro:
  This study is the first investigation of the cytoprotective effects of GPF against hydrogen peroxide (H2O2)-induced cell injury and death in human HaCaT keratinocytes. GPF demonstrated a significant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H2O2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2 (-)), and the hydroxyl radical ( OH). GPF also safeguarded HaCaT keratinocytes against H2O2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins. The compound exerted its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylated protein species
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROS, Inhibitor, Galloylpaeoniflorin, inhibit, Nuclear factor-kappaB, Nuclear factor-κB, NF-κB, NFκB, NF-kB, NFkB, 6'-O-Galloyl paeoniflorin, Androgen Receptor, AndrogenReceptor

Compound Identifiers

PubChem CID

101604718