Gallic acid

SKU: orb1310208

Description

Gallic acid

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 149-91-7
• MW: 170.12
• Purity: 99.38%
• Formula: C₇H₆O₅
• SMILES: OC(=O)C1=CC(O)=C(O)C(O)=C1
• Target: Reactive Oxygen Species,Ferroptosis,ROS,Apoptosis,Endogenous Metabolite,COX
• Solubility: Ethanol:32 mg/mL (188.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (29.39 mM);H2O:7 mg/mL (41.15 mM);DMSO:255 mg/mL (1498.94 mM)

Bioactivity

• Target IC50:
  HCT15 cells proliferation:740 μM|Aldose reductase:3.05 µg/mL|thrombin:9.07 μM
• In Vivo:
  Gallic acid effectively protects rat erythrocytes the antioxidant effect o the compound a the tested dosage in vivo was more prevalent than its prooxidative effects. Gallic acid has ameliorative effect on lipid peroxidation in viv.
• In Vitro:
  Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. It reduce the viability of PC12 cells in a dose-dependent manner. Gallic acid also induces cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. Gallic acid induce the phosphorylation of c-Jun N-terminal protein kinase (JNK) an the downregulation of Bcl-2 in PC12 cells. Gallic acid leads to a progressive reduction in the viability of vector-transfected PC12 cells, which is delayed in PC12 cells that overexpressed Bcl-.
• Cell Research:
  Cell viability is measured usin the MTT assay. PC12 cells are incubated at 37℃ith Water2 or gallic acid at different concentration for 24 h with or without pretreatment with resveratrol. They are then treated wit the MTT solution final concentration 1 mg/mL) for 2 h the dark-blue formazan crystals that formed in intact cells are dissolved in DMSO, an the absorbance at 570 nM is measured using a micro-ELISA reader.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

COX, Endogenous Metabolite, Apoptosis, 3,4,5-Trihydroxybenzoic acid, EndogenousMetabolite, Ferroptosis, Gallate, Gallic acid, ROS, ReactiveOxygenSpecies, Reactive Oxygen Species

Compound Identifiers

PubChem CID

370