Gallic Acid Monohydrate

SKU: orb2944194

Description

Gallic Acid Monohydrate, the hydrated form of the natural polyhydroxyphenol Gallic Acid, acts as a COX-2 inhibitor with antioxidant properties. It is widely used in research for its anti-inflammatory, antitumor, and antibacterial activities, studied in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 5995-86-8
• MW: 188.14
• Purity: 98.02% (May vary between batches)
• Formula: C₇H₈O₆
• SMILES: O=C(O)C1=CC(O)=C(O)C(O)=C1.O
• Target: Reactive Oxygen Species,ROS,Apoptosis,Endogenous Metabolite,COX,Ferroptosis
• Solubility: DMSO:40 mg/mL (212.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.63 mM)

Bioactivity

• In Vivo:
  In TMT- and ICV-STZ–induced Alzheimer's disease (AD) rat models, Gallic Acid Monohydrate was orally administered at doses of 30, 50, or 100 mg/kg. Treatment increased hippocampal BDNF and TNF-α levels, improved passive avoidance and memory performance, enhanced antioxidant enzyme activities including SOD, CAT, and GPx, and reduced TBARS levels in the hippocampus, indicating neuroprotective and cognitive-enhancing effects.
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• In Vitro:
  In RAW264.7 macrophages, Gallic Acid Monohydrate (0–100 μM) inhibited LPS-induced NF-κB activation and significantly reduced the production of proinflammatory mediators including nitric oxide (NO), IL-6, and TNF-α. In human corneal epithelial cells (HCECs), Gallic Acid Monohydrate (0–100 μM) suppressed hyperosmotic stress-induced reactive oxygen species (ROS) generation and upregulated antioxidant enzymes such as Nrf2, HO-1, and NQO1. In peripheral blood mononuclear cells (PBMCs) from psoriasis patients, gallic acid (0–100 μM) significantly decreased the frequency of IFN-γ– and IL-17–producing T cell subsets.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3,4,5-Trihydroxybenzoic acid Monohydrate, 3,4,5-Trihydroxybenzoic acid hydrate, Gallic acid hydrate

Compound Identifiers

PubChem CID

24721416