Galgravin

SKU: orb1297593

Description

Galgravin

Research Area

Cell Biology

Key Properties

• CAS Number: 528-63-2
• MW: 372.45
• Purity: 99.88% (May vary between batches)
• Formula: C₂₂H₂₈O₅
• SMILES: C[C@@H]1[C@H](O[C@H]([C@@H]1C)C2=CC(OC)=C(OC)C=C2)C3=CC(OC)=C(OC)C=C3
• Target: Apoptosis
• Solubility: DMSO:9 mg/mL (24.16 mM)

Bioactivity

• In Vitro:
  This approach resulted in the isolation and characterization of eight tetrahydrofuran neolignans: calopeptin (1), machilin-G (2), machilin-I (3), aristolignin (4), nectandrin A (5), veraguensin (6), ganschisandrin (7), and Galgravin (8). Different assays were conducted to evaluate their cytotoxic activities and to determine the possible mechanism(s) related to the activity displayed against human leukemia cells. The most active compounds 4, 5 and 8 gave IC50 values of 14.2 ± 0.7, 16.9 ± 0.8 and 16.5 ± 0.8 μg/mL, respectively, against human leukemia (HL-60) tumor cells. Moreover, these compounds induced specific apoptotic hallmarks, such as plasma membrane bleb formation, nuclear DNA condensation, specific chromatin fragmentation, phosphatidyl-serine exposure on the external leaflet of the plasma membrane, cleavage of PARP as well as mitochondrial damage, which as a whole could be related to the intrinsic apoptotic pathway.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Amyloid, Apoptosis, PARP, inhibit, Inhibitor, Galgravin, p38

Compound Identifiers

PubChem CID

101749