GA-017

SKU: orb1689850

Description

GA-017 is a potent and selective LATS1/2 kinase inhibitor that activates YAP/TAZ signaling, promoting cell proliferation and growth. It enhances 3D cell culture growth and ex vivo intestinal organoid formation, making it a valuable research tool for studying the Hippo pathway in cancer, regenerative biology, and organoid development.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2351906-74-4
• MW: 343.38
• Purity: 99.38% (May vary between batches)
• Formula: C₁₈H₂₁N₃O₄
• SMILES: CC\C(=N\NC(=O)NCc1cccc(O)c1)c1ccc(O)c(C)c1O
• Target: YAP,Others
• Solubility: DMSO:150 mg/mL (436.83 mM)

Bioactivity

• In Vitro:
  GA-017 suppresses the HUVECs cell death and promotes their cell growth . GA-017 facilitates SKOV3 cell growth, with an EC 50 of 3.51 ± 0.26 μM . GA-017 competitively inhibited LATS1 and 2 against ATP, with K i (inhibition constant) values of 0.58 ± 0.11 and 0.25 ± 0.03 nM, respectively .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lats2, Lats1, GA017, GA-017, GA 017

Compound Identifiers

PubChem CID

147467531