G721-0282

SKU: orb3135613

Description

G721-0282 is an orally active inhibitor of CHI3L1 that reduces the expression of inflammatory proteins and cytokines. It suppresses the activation of the NF-κB signaling pathway, inhibits neuroinflammation, and decreases anxiety-related behaviors. Additionally, G721-0282 significantly curtails the proliferation of osteosarcoma (OS) cells by inhibiting the STAT3 signaling pathway and induces apoptosis in OS cells by upregulating pro-apoptotic protein levels while downregulating anti-apoptotic protein levels. This compound is useful in the study of neuroinflammatory diseases and cancer.

Key Properties

• CAS Number: 946378-12-7
• MW: 376.47
• Formula: C₁₈H₂₄N₄O₃S
• SMILES: O=C1C2=C(SCC(=O)NCC=C)C(=CN=C2N(C(=O)N1C)C)CCCC
• Target: Apoptosis,CDK,STAT,COX,p38 MAPK,ERK,Survivin,glycosidase,Bcl-2 Family,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,CDK,STAT,COX,p38 MAPK,ERK,Survivin,glycosidase,Bcl-2 Family,NF-κB