G721-0282

SKU: orb3135613

Description

G721-0282 is an orally active inhibitor of CHI3L1 that reduces the expression of inflammatory proteins and cytokines. It suppresses the activation of the NF-κB signaling pathway, inhibits neuroinflammation, and decreases anxiety-related behaviors. Additionally, G721-0282 significantly curtails the proliferation of osteosarcoma (OS) cells by inhibiting the STAT3 signaling pathway and induces apoptosis in OS cells by upregulating pro-apoptotic protein levels while downregulating anti-apoptotic protein levels. This compound is useful in the study of neuroinflammatory diseases and cancer.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 946378-12-7
• MW: 376.473
• Formula: C₁₈H₂₄N₄O₃S
• SMILES: CCCCC1=C(SCC(=O)NCC=C)C2=C(N=C1)N(C)C(=O)N(C)C2=O
• Target: glycosidase,Bcl-2 Family,COX,p38 MAPK,ERK,NF-κB,Apoptosis,STAT,CDK,Survivin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

glycosidase,Bcl-2 Family,COX,p38 MAPK,ERK,NF-κB,Apoptosis,STAT,CDK,Survivin