G6PDi-1

SKU: orb1298754

Description

G6PDi-1 is a potent and selective small molecule inhibitor of glucose-6-phosphate dehydrogenase. By inhibiting G6PD, it effectively depletes cellular NADPH and reduces the production of pro-inflammatory cytokines, making it a valuable research tool for studying redox biology, immunometabolism, and inflammation in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2457232-14-1
• MW: 284.34
• Purity: 98.69% (May vary between batches)
• Formula: C₁₄H₁₂N₄OS
• SMILES: O=C1CCCCc2nc(Nc3csc(c3)C#N)ncc12
• Target: Dehydrogenase,Others
• Solubility: DMSO:25 mg/mL (87.92 mM)

Bioactivity

• In Vitro:
  G6PDi-1 effectively inhibits G6PD. Across a range of cultured cells, G6PDi-1 depletes NADPH most strongly in lymphocytes. In T cells but not macrophages, G6PDi-1 markedly decreases inflammatory cytokine production. In neutrophils, it suppresses respiratory burst.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

G6PD, G6PDi 1, G6PDi1, G-6PDi-1, G6PDi-1

Compound Identifiers

PubChem CID

145998284