G6PD activator AG1

SKU: orb1709650

Description

AG1 is a small molecule agonist that activates glucose-6-phosphate dehydrogenase (G6PD) by promoting its functional oligomerization. It is used in research to mitigate oxidative stress in models including human erythrocytes, cultured cells, and zebrafish, providing a tool for studying G6PD deficiency and related redox biology.

Research Area

Metabolism Research

Key Properties

• CAS Number: 421581-52-4
• MW: 438.65
• Purity: 99.51% (May vary between batches)
• Formula: C₂₄H₃₀N₄S₂
• SMILES: S(SCCNCCC1=CNC=2C=CC=CC21)CCNCCC3=CNC=4C=CC=CC43
• Target: NADPH,Others,Dehydrogenase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.56 mM);DMSO:15 mg/mL (34.2 mM)

Bioactivity

• Target IC50:
  G6PD:3 µΜ
• In Vitro:
  G6PD activator AG1 (1-5 μΜ; pre-incubated overnight) reduces the extent of hemolysis with 5 μΜ in human erythrocytes suspension (5%) exposed to either 1 mM chloroquine (CQ; 4 hours) or diamide (a GSH oxidant; 4 hours). G6PD activator AG1 increases GSH levels and reduced ROS levels together with increased G6PD activity under these drug-induced oxidative stress. G6PD activator AG1 (50, 100, 250, 500, 750, 1000 nM) increases the viability by 20% and the proteolytic stability of Canton G6PD in SH-SY5Y cells. G6PD activator AG1 has no effect when G6PD was knocked down by siRNA, supporting the specificity of G6PD activator AG1 toward G6PD.

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

G6PD activator AG1, G-6PD activator AG1, G6PD

Compound Identifiers

PubChem CID

6615809