G36

SKU: orb1704521

Description

G36 is a potent and selective cell-permeable GPER antagonist, effectively blocking estrogen- and G-1-induced signaling (IC50 ~112-165 nM) without activity on ERα/ERβ. It is a valuable pharmacological tool used in vitro and in vivo to dissect GPER-specific functions in cancer, cardiovascular, and metabolic research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1392487-51-2
• MW: 412.32
• Purity: 99.86% (May vary between batches)
• Formula: C₂₂H₂₂BrNO₂
• SMILES: [H][C@]12CC=C[C@@]1([H])c1cc(ccc1N[C@H]2c1cc2OCOc2cc1Br)C(C)C
• Target: Estrogen Receptor/ERR
• Solubility: DMSO:55 mg/mL (133.39 mM)

Bioactivity

• Target IC50:
  GPER:165 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

G36, G-36, EstrogenReceptor, Estrogen Receptor, GPER, ERR, G 36

Compound Identifiers

PubChem CID

73755224