G150

SKU: orb1309652

Description

G150 is a potent and selective inhibitor of human cGAS (h-cGAS), effectively suppressing dsDNA-induced interferon expression with an IC50 of 10.2 nM. This small molecule is a valuable research tool for studying the cGAS-STING pathway in autoimmune, inflammatory, and cancer research contexts, applicable in both cellular and animal models.

Research Area

Immunology & Inflammation, Molecular Biology

Key Properties

• CAS Number: 2369751-30-2
• MW: 391.25
• Purity: 97.75% (May vary between batches)
• Formula: C₁₈H₁₆Cl₂N₄O₂
• SMILES: Nc1ccc(cn1)-c1cc(Cl)c(Cl)c2[nH]c3CCN(Cc3c12)C(=O)CO
• Target: cGAS|||DNA
• Solubility: DMSO:83.33 mg/mL (212.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.22 mM)

Bioactivity

• Target IC50:
  cGAS (human):10.2 nM
• In Vitro:
  G150 showed dose-dependent inhibitory activity in THP1 cells with cellular IC50 of 1.96 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

THP1, high-throughput screening, Inhibitor, h-cGAS, G150, G-150, G 150, human myeloid cell, macrophage, inhibit, anti-inflammatory, cGAS, Cyclic GMP-AMP Synthase, dsDNA, dsDNA/cGAS

Compound Identifiers

PubChem CID

138393372