G15

SKU: orb1299863

Description

G15

Research Area

Metabolism Research

Key Properties

• CAS Number: 1161002-05-6
• MW: 370.24
• Purity: ≥98% (May vary between batches)
• Formula: C₁₉H₁₆BrNO₂
• SMILES: Brc1cc2OCOc2cc1[C@@H]1Nc2ccccc2[C@@H]2C=CC[C@H]12
• Target: Estrogen Receptor/ERR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.4 mM);DMSO:41.67 mg/mL (112.55 mM)

Bioactivity

• Target IC50:
  GPER:20 nM(Ki)
• In Vivo:
  G-15 antagonizes the anti-depressive effects of estrogen in vivo.
• Animal Research:
  G15 and G1 were first dissolved in DMSO and diluted with saline; the final concentration in DMSO was 1 mM. Desipramine and E2 (cyclodextrin-encapsulated, 4-5.5% E2) were dissolved in saline solution and DMSO was added to a final concentration of 1 mM. An appropriate vehicle-treated group (saline with 1 mM DMSO) was included as a control (sham). All solutions were freshly prepared before each experimental series. Independent groups of mice (n=12-16) were treated with two consecutive intraperitoneal injections as follows: vehicle solution + vehicle solution (sham group); vehicle + G-1 (indicated amount in nmol); vehicle + desipramine (10mg/kg); G15 (10nmol/mouse) + desipramine (10mg/kg); G15 (10nmol/mouse) + G-1 (1nmol/mouse); vehicle + G15 (10nmol/mouse); vehicle + soluble E2 (5 mg/kg); G15 (25nmol/mouse) + soluble E2 (5 mg/kg). The second compound was injected 15 min (7 min for E2) after the first injection and the tail suspension test performed 30 min after the second injection.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, EstrogenReceptor, Estrogen Receptor/ERR, Estrogen Receptor, GPER, G 15, G15, G-15, ERR

Compound Identifiers

PubChem CID

7433743