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G140

SKU: orb1298276

Description

G140 is a potent and selective small molecule inhibitor of the cGAS enzyme. It is a valuable research tool for investigating the cGAS-STING signaling pathway in both cellular and animal models of autoimmunity, inflammation, and cancer.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2369751-07-3
MW379.24
Purity98.63% (May vary between batches)
FormulaC17H16Cl2N4O2
SMILESClC1=C2C(C3=C(N2)CCN(C(CO)=O)C3)=C(C=C1Cl)C=4C=CN(C)N4
TargetcGAS
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.18 mM);DMSO:247 mg/mL (651.3 mM)

Bioactivity

Target IC50
cGAS (mouse):442 nM|cGAS (human):14 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

anti-inflammatory, cyclic, Cyclic GMP-AMP Synthase, cGAS, inhibit, Inhibitor, GMP-AMP, G140, G-140, G 140, synthase

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  • G140 [orb1218337]

    >98% (HPLC)

    2369751-07-3

    379.24

    C17H16Cl2N4O2

    25 mg, 200 mg, 50 mg, 1 g, 500 mg, 5 mg, 10 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 120.00
1 ml x 10 mM (in DMSO)
$ 230.00
5 mg
$ 270.00
10 mg
$ 390.00
25 mg
$ 610.00
50 mg
$ 890.00
100 mg
$ 1,200.00
200 mg
$ 1,600.00
DispatchUsually dispatched within 5-10 working days
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