G12Si-5

SKU: orb1685980

Description

G12Si-5 is a covalent inhibitor targeting the K-RasG12S mutant, binding its S-IIP domain with a Ki of 26 µM to suppress oncogenic signaling. It effectively reduces ERK phosphorylation in KRAS G12S mutant cell lines, making it a valuable tool for in vitro cancer research, though its powder form is unstable, necessitating stabilized salt formulations.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2946593-46-8
• MW: 574.05
• Formula: C₃₁H₂₉ClFN₅O₃
• SMILES: C(OC=1N=C(C2=C(N1)C(F)=C(N=C2)C=3C4=C(C=CC3)C=CC=C4Cl)N5C[C@]6([C@@](CC5)(C(=O)O6)[H])[H])C78N(CCC7)CCC8
• Target: Others,Ras,Kras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164510765