G-749 hydrochloride

SKU: orb1738883

Description

G-749 hydrochloride is a potent and selective FLT3 inhibitor effective against wild-type and mutant forms, including ITD and resistance-conferring variants like D835Y and F691L. It demonstrates robust activity in cellular assays and has shown efficacy in preclinical models of FLT3-driven acute myeloid leukemia (AML), supporting its use in both in vitro and in vivo research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1457983-33-3
• MW: 557.88
• Formula: C₂₅H₂₆BrClN₆O₂
• SMILES: Cl.CN1CCC(CC1)Nc1nc(Nc2ccc(Oc3ccccc3)cc2)c2c(n1)c(Br)c[nH]c2=O
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

86279996