FzM1

SKU: orb1703438

Description

FzM1 is a negative allosteric modulator of FZD4 that binds intracellularly to ICL3, inhibiting WNT5A-driven WNT/β-catenin signaling with a log EC50inh of -6.2. This small molecule is a valuable research tool for investigating FZD4 function in both cellular and animal models of development and disease.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1680196-54-6
• MW: 360.43
• Purity: 99.89% (May vary between batches)
• Formula: C₂₁H₁₆N₂O₂S
• SMILES: Oc1cc(NC(=O)Nc2ccc3ccccc3c2)cc(c1)-c1cccs1
• Target: Wnt/beta-catenin
• Solubility: DMSO:65 mg/mL (180.34 mM)

Bioactivity

• In Vitro:
  FzM1 inhibited Gli activity less efficiently than TCF/LEF activity (log EC50 of −4.6 and −5.7, respectively). On the contrary, it did not modulate CRE activity (log EC50 > −4.0), indicating that it does not influence GPCRs linked to G proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Wnt, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, βcatenin, beta-catenin, betacatenin, bcatenin, FZD4, FzM 1, FzM1, FzM-1

Compound Identifiers

PubChem CID

90478321