FZD7 antagonist 1

SKU: orb2563765

Description

FZD7 antagonist 1 (peptide 34) is a dFz7-21 analog that potently inhibits Wnt3a signaling (IC50 = 9.2 nM) and disrupts the TcdB-FZD interaction. This cell-permeable peptide is a valuable tool for investigating FZD-mediated Wnt pathway biology in both cellular and in vivo models of development and disease.

Research Area

Signal Transduction, Stem Cell & Developmental Biology, Stem Cell & Developmental Biology; Pharmacology & Drug Discovery

Key Properties

• Target: Wnt/beta-catenin
• CAS Number: 2416664-25-8
• MW: 3157.57
• Formula: C₁₄₂H₂₀₂N₃₂O₄₂S₄
• SMILES: C([C@@H](C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N)=O)=O)CCSC)=O)[C@H](CC)C)=O)=O)CSSC[C@H](NC([C@H](CC=3C=4C(NC3)=CC=CC4)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)[C@@H](C)O)=O)CC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CC(C)C)=O)=O)C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@H](C(N[C@@H](CC6=CC=C(O)C=C6)C(N)=O)=O)CCSC)=O)[C@H](CC)C)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)[C@@H](C)O)=O)CC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CC(C)C)=O)C=7C=8C(NC7)=CC=CC8

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172653475