FXR agonist 17

SKU: orb3211430

Description

FXR agonist17 is an orally active, steroidal FXR agonist with EC50 values of 42.2 nM (TR-FRET) and 176.4 nM (luciferase reporter assay). It can activate TGR5 (EC50 = 2.6 μM) but does not activate hMRGPRX4. FXR agonist17 exhibits anti-inflammatory, hepatoprotective, and antifibrotic effects, improving the activity score of metabolic dysfunction-associated fatty liver disease (NAFLD) and reducing the severity of liver fibrosis. This compound is applicable for research in NAFLD, cholestatic liver diseases, and liver fibrosis.

Key Properties

• CAS Number: 3107769-23-0
• MW: 502.75
• Formula: C₂₉H₄₆N₂O₃S
• SMILES: O[C@H]1[C@@]2([C@@]([C@]3(C)[C@]([C@H]1CC)(C[C@H](O)CC3)[H])(CC[C@@]4(C)[C@]2(CC[C@@]4([C@@H](CCC5=CC(=O)NC(=S)N5)C)[H])[H])[H])[H]
• Target: FXR,GPCR19,TNF,ROS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

FXR,GPCR19,TNF,ROS