Fuziline

SKU: orb1303419

Description

Fuziline is an aconitane-type diterpenoid alkaloid isolated from Aconitum species. It serves as a research tool for studying the pharmacology of natural products, with applications in both in vitro and in vivo models to investigate its biological activities.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 80665-72-1
• MW: 453.57
• Purity: 99.96% (May vary between batches)
• Formula: C₂₄H₃₉NO₇
• SMILES: [H][C@]12C[C@]3([H])[C@]([H])([C@H]1O)[C@@](O)(C1[C@H](OC)[C@@]4([H])C33C1N(CC)C[C@]4(COC)CC[C@@H]3O)[C@@H](O)[C@@H]2OC
• Target: Anti-infection
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.41 mM);DMSO:50 mg/mL (110.24 mM)

Bioactivity

• In Vitro:
  In the in vitro assays,fuziline increases cell viability in the model of ISO‐induced injury.
• Cell Research:
  Rat cardiomyocytes(H9c2）were cultured in 96-well plates with High‐glucose DMEM added with 10% FBS,100 μg/mL streptomycin and 100 U/mL penicillin,and H9c2 cells were placed in an incubator with 37°C and 5% CO2 for 24 hours. then addressed with isoproterenol(ISO) and different concentrations of fuziline for the indicated time. Then, the DMEM was removed and 100 μL MTT solution (0.1 mg/well) was added, and H9c2 cells were incubated for 3 hours. After that, the supernatant was removed and the formazan crystals were dissolved in 150 μL DMSO. Then, the absorbance of each sample was detected at 490 nm by a microplate reader.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fuziline, inhibit, Inhibitor, Anti-infection, Antiinfection, 15α-Hydroxyneoline

Compound Identifiers

PubChem CID

131954769