FUT8-IN-1

SKU: orb2945515

Description

FUT8-IN-1 (Compound 37) is a potent small molecule inhibitor of α-1,6-fucosyltransferase (FUT8) with a KD of 49 nM. It acts via enzyme-activated generation of a naphthoquinone imine intermediate, effectively blocking FUT8 activity. This inhibitor is a valuable research tool for studying protein fucosylation in cancer biology and antibody-dependent cellular cytotoxicity (ADCC) enhancement in both cellular and biochemical assays.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• MW: 380.91
• Formula: C₂₃H₂₅ClN₂O
• SMILES: CCN1CCN(C(C1)C2=CC=CC=C2)CC3=C(C=CC4=C3C=CC(=C4)Cl)O
• Target: Transferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677010