Fusarochromanone

SKU: orb1703439

Description

Fusarochromanone (FC-101) is a Fusarium marcescens-derived mycotoxin exhibiting antiangiogenic, anticancer, and antimalarial properties. Research indicates it induces apoptosis in cell lines like COS7 and HEK293 via JNK pathway activation, supporting its investigation in oncology and parasitology for both in vitro and in vivo studies.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 802915-53-3
• MW: 292.33
• Purity: 96.00% (May vary between batches)
• Formula: C₁₅H₂₀N₂O₄
• SMILES: NC1=C2C(=CC=C1C(C[C@H](CO)N)=O)OC(C)(C)CC2=O
• Target: ROS,Reactive Oxygen Species

Bioactivity

• In Vivo:
  Fusarochromanone (8 mg/kg; administered intraperitoneally 5 days per week for 3.5 weeks) treatment of SCID Beige mice inoculated with SRB12-p9 cells resulted in a 30% reduction in tumor volume.
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• In Vitro:
  Fusarochromanone (10 μM; 24 hours) treatment of HaCaT and P9-WT cell lines resulted in cells being in the G2 and M phases of the cell cycle for both cell lines.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ReactiveOxygenSpecies, Reactive Oxygen Species, NSC 627608, NSC627608, NSC-627608, Fusarochromanone, FC101, FC-101, FC 101

Compound Identifiers

PubChem CID

363059