Furazolidone

SKU: orb1310325

Description

Furazolidone

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 67-45-8
• MW: 225.16
• Purity: 99.98%
• Formula: C₈H₇N₃O₅
• SMILES: C(=NN1C(=O)OCC1)C=2OC(N(=O)=O)=CC2
• Target: MAO,Antibiotic,Parasite,Antibacterial,Apoptosis
• Solubility: DMSO:7.5 mg/mL (33.31 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  AML1-ETO:12.7 μM
• In Vivo:
  FZ accelerates its own metabolism in the chicken by induction o the activity of CPR whereas no effect is observed in the ra.
• In Vitro:
  Furazolidone displays potent ant Proliferative properties at submicromolar concentration and induces apoptosis in mL cell lines. Furazolidone treatment of certain mL cells induces myeloid cell differentiation by morphology and flow cytometry for CD11b expression, resulting in increased stability of tumor suppressor p53 protein in mL cell.
• Cell Research:
  Leukemic cells are seeded in 96-well culture plates at a density of 1 or 2×104 viable cells/100 µl/well in triplicates and are treated for 24, 48, and 72 hours with an incremental concentration of FZD ranging from 1 µM to 50 µM. Colorimetric CellTiter 96® Aqueous One Solution Cell Proliferation assay is used to determin the cytotoxicity the optical density at 492 nM is measured using a Multiskan Ascent® microplate photometer. IC50 Values are determined by MTS assay when cells are treated with FZD for 72 hours and calculated with GraphPad Prism 5. Each experiment was in triplicate. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Antibiotic, Apoptosis, Bacterial, inhibit, Inhibitor, Furoxone, Furazolidone, MAO

Compound Identifiers

PubChem CID

3435