Furaprofen

SKU: orb1706738

Description

Furaprofen is an orally bioavailable, selective HCV inhibitor with demonstrated anti-inflammatory properties. It reduces carrageenan-induced paw edema and, at higher doses, inhibits cotton pellet-induced granuloma formation in rat models, supporting its study in viral hepatitis and inflammation research.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 67700-30-5
• MW: 266.29
• Purity: 99.52% (May vary between batches)
• Formula: C₁₇H₁₄O₃
• SMILES: CC(C(O)=O)c1cccc2c(coc12)-c1ccccc1
• Target: HCV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.78 mM);DMSO:200 mg/mL (751.06 mM)

Bioactivity

• Target IC50:
  HCV 1a/1b:（EC50）~30 nM|HCV 2a:~1000 nM（EC50）
• In Vitro:
  The effectiveness of Furaprofen in inhibiting the replicon is verified through Western blotting and TaqMan RT-PCR, yielding IC50 values of approximately 37 nM and 54.67±4.11 nM, respectively. Furthermore, its antiviral potency, assessed via a reporter replicon assay conducted through multiple iterations, demonstrates a significant increase, standing at 29.88±8.05 nM—indicating an approximately threefold enhancement when compared to its precursor compound, R706. To evaluate Furaprofen's broader impact on cell proliferation, diverse primary and transformed human cell lines were subjected to escalating doses of the compound over a 48-hour period. The resultant effect on cell proliferation was quantified using an MTS-based cell viability assay, revealing the CC50 (the concentration required to diminish cell numbers by 50% in the absence of viral infection) of Furaprofen to vary between 2 μM and ≥10 μM, contingent upon the specific cell type and its proliferation state.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R 803, R-803, R803, HCV Protease, HCVProtease, HCV, HCV genotype 1a and 1b replicons, HCV genotype 2a replicon, Furaprofen

Compound Identifiers

PubChem CID

37801