Furamidine dihydrochloride

SKU: orb1700535

Description

Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that competitively targets the enzyme's active site. It also exhibits minor groove DNA binding affinity for AT-rich sequences. This compound demonstrates anti-proliferative activity in various leukemia cell lines in vitro, supporting its use in oncology and epigenetics research.

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 55368-40-6
• MW: 377.27
• Purity: 98.16% (May vary between batches)
• Formula: C₁₈H₁₈Cl₂N₄O
• SMILES: N=C(C1=CC=C(C2=CC=C(C3=CC=C(C(N)=N)C=C3)O2)C=C1)N.Cl.Cl
• Target: PDE,Histone Methyltransferase,Parasite
• Solubility: DMSO:10 mg/mL (26.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.65 mM)

Bioactivity

• Target IC50:
  PRMT6:283 µM (IC50)|PRMT4:>400 µM (IC50)|PRMT5:166 µM (IC50)|Protein arginine methyltransferase 1 (PRMT1):9.4 μM (IC50)
• In Vivo:
  Furamidine dihydrochloride (1 mg/kg, intraperitoneal injection, 3 times a week, repeated every 4 weeks for 34 weeks) was used to treat female NZB/NZW mice and was found to suppress proteinuria and prolong the survival of lupus-prone NZB/NZW mice when combined with irinotecan.
• In Vitro:
  Furamidine dihydrochloride (20 μM, 72 hours) treatment of leukemia cell lines inhibited cell growth in most leukemia cell lines except HEL cells harboring the JAK2V617F mutation.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Furamidine Dihydrochloride, Furamidine dihydrochloride, Furamidine HCl, Furamidine, NSC305831 dihydrochloride, NSC 305831 dihydrochloride, DB 75, DB75, NSC 305831, WR 199385, DB 75, DB75, NSC 305831, WR199385, DB 75, DB75, NSC 305831, WR-199385, DB75 dihydrochloride

Compound Identifiers

PubChem CID

9799856