β-Funaltrexamine

SKU: orb3174882

Description

β-Funaltrexamine (β-FNA) is a selective, irreversible antagonist of the μ opioid receptor (μopioid receptor) with anti-inflammatory and neuroprotective properties. It reduces TLR4 signaling, inhibits cytokine-induced iNOS activation and neuroinflammation, and improves neuronal degeneration. Additionally, β-Funaltrexamine suppresses NF-κB signaling and chemokine expression in human astrocytes and mice. This compound is utilized in research for neurodegenerative diseases, such as stroke.

Key Properties

• CAS Number: 72782-05-9
• MW: 454.52
• Formula: C₂₅H₃₀N₂O₆
• SMILES: O[C@]12[C@@]34C=5C(O[C@]3([C@H](NC(/C=C/C(OC)=O)=O)CC1)[H])=C(O)C=CC5C[C@]2(N(CC6CC6)CC4)[H]
• Target: Opioid Receptor,NO Synthase,NF-κB,TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Opioid Receptor,NO Synthase,NF-κB,TLR