Fucoidan

SKU: orb1299723

Description

Fucoidan

Research Area

Metabolism Research

Key Properties

• CAS Number: 9072-19-9
• MW: 256.27
• Purity: ≥98% (May vary between batches)
• Formula: C₈H₁₆O₇S
• SMILES: CO[C@@H]1[C@@H](C)O[C@@H](C)[C@@H](OS(O)(=O)=O)[C@H]1O
• Target: Others,Glucosidase,glycosidase
• Solubility: H2O:10 mM;DMSO:Insoluble

Bioactivity

• In Vivo:
  Intraperitoneal injection of fucoidan in breast cancer models reduced the tumor volume and weight. The enhanced antitumor efficacy was associated with decreased angiogenesis and increased induction of apoptosis.
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• In Vitro:
  Fucoidan significantly decreased viable cell number in a dose-response manner with an IC50 of 550 ±4.3 μg/mL. Cell morphology was altered and significant apoptosis was induced when cells were exposed to 550 μg/mL fucoidan for 48 h.
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• Cell Research:
  The influence of fucoidan on B16 melanoma cells and cellular tyrosinase:Cell viability was examined by the cell counting kit-8 assay. Cellular tyrosinase activity and melanin content were determined using spectrophotometric methods and protein expression was analyzed by immunoblotting. Morphological changes in B16 melanoma cells were examined by phase contrast microscopy and apoptosis was analyzed by flow cytometry.
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• Animal Research:
  In vivo, therapy experiments were conducted on Babl/c mice bearing breast cancer. The tumor volume and weight were measured. The number of apoptotic cells and microvascular density (MVD) in tumor tissues were assessed by TUNEL and CD34 immunostaining. Immunohistochemical assays and ELISA assay were used to detect the expression of VEGF in tissues.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anticancer, anticoagulant, antisteatotic, diabetes, Fucoidan, Glucosidase, Inhibitor, inhibit, polysaccharide, Type 2, α-amylase, α-glucosidase. Antioxidant

Compound Identifiers

PubChem CID

129532628