FTBMT

SKU: orb1308289

Description

FTBMT is a potent and selective GPR52 agonist with an EC50 of 75 nM. It exhibits antipsychotic and cognitive-enhancing properties, making it a valuable research tool for investigating neuropsychiatric disorders in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1358575-02-6
• MW: 392.35
• Purity: 99.56% (May vary between batches)
• Formula: C₁₉H₁₆F₄N₄O
• SMILES: Cc1nc(Cc2cc(F)cc(c2)C(F)(F)F)nn1-c1ccc(C(N)=O)c(C)c1
• Target: GPCR
• Solubility: DMSO:45 mg/mL (114.69 mM);H2O:< 0.1 mg/mL (insoluble);10% DMSO+90% Corn Oil:2 mg/mL (5.1 mM)

Bioactivity

• Target IC50:
  GPR52:75 nM(EC50)
• In Vivo:
  In rats, FTBMT (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory. FTBMT (30 mg/kg, 90 minutes) shows antipsychotic-like activity without causing catalepsy in mice
• In Vitro:
  In CHO cells expressing human, mouse, or rat GPR52, FTBMT (0.1-10 μM) improves intracellular cAMP levels (pEC50s of 7.03, 6.85, and 6.87, respectively).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, FTBMT, GPR52, inhibit

Compound Identifiers

PubChem CID

56649300