FT113

SKU: orb1299359

Description

FT113 is a potent small molecule inhibitor of fatty acid synthase (FASN) with an IC50 of 213 nM. It demonstrates anti-cancer activity in vitro and has shown efficacy in reducing tumor growth in vivo, making it a valuable tool for oncology and metabolic disease research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1630808-89-7
• MW: 409.41
• Purity: 97.05% (May vary between batches)
• Formula: C₂₂H₂₀FN₃O₄
• SMILES: OC1(CC1)C(=O)N1CCN(CC1)C(=O)c1ccc(cc1)-c1nc2ccc(F)cc2o1
• Target: Fatty Acid Synthase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.89 mM);DMSO:62.5 mg/mL (152.66 mM)

Bioactivity

• Target IC50:
  Fas:213 nM
• In Vivo:
  FT113, a compound with potent biochemical and cellular activity, which translated into excellent activity in in vivo models.Caused 32 % and 50% tumor growth inhibition at 25 and 50 mg/kg, respectively in mice.
• Animal Research:
  Athymic nude mice bearing MV-411 cells. Dosage:5, 25, or 50 mg/kg, twice daily for 16 days

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, FT 113, FT113, FT-113, FAS, Fatty Acid Synthase, Fatty Acid Synthase (FASN), FattyAcidSynthase, inhibit

Compound Identifiers

PubChem CID

118621601