FT-1518

SKU: orb1709666

Description

FT-1518 is a potent, selective, and orally bioavailable dual inhibitor of mTORC1 and mTORC2. It demonstrates anticancer activity in research, facilitating mechanistic studies and therapeutic evaluation in both cellular (in vitro) and animal (in vivo) models of cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1313026-58-2
• MW: 394.47
• Purity: 98.80%
• Formula: C₂₀H₂₆N₈O
• SMILES: N=1C=C(N=CC1N)C2=NC(=NC3=C2N=CN3C(CC)CC)N4CC5OC(C4)CC5
• Target: mTOR
• Solubility: DMSO:2 mg/mL (5.07 mM)

Bioactivity

• In Vivo:
  FT-1518 showed high sustained tumor exposure and target Inhibition in a single oral dose xenograft model. FT-1518 exhibited dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts compared with rapalogs and is poised to enter the clinic with a favorable toxicology profile.
• In Vitro:
  FT-1518 depicted very good growth inhibitory activity across a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. mTOR kinase inhibition in cells, by FT-1518, resulted in more potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)], and improved anti-proliferative activity as compared with rapamycin.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTORC1, mTORC2, FT 1518, FT-1518

Compound Identifiers

PubChem CID

53258965