FSEN1

SKU: orb1944716

Description

FSEN1 is a potent and novel non-competitive FSP1 inhibitor (IC50 = 313 nM) that induces ferroptosis in cancer cells. It is a valuable research tool for investigating ferroptosis mechanisms and has demonstrated efficacy in both in vitro cellular assays and in vivo tumor model studies for cancer research.

Research Area

Cell Biology

Key Properties

• CAS Number: 862808-01-3
• MW: 484.41
• Purity: 98.56% (May vary between batches)
• Formula: C₂₂H₂₂BrN₅OS
• SMILES: COC1=CC=C(C=C1)N1CCN(CC2=CN3C(S2)=NN=C3C2=CC=C(Br)C=C2)CC1
• Target: Ferroptosis

Bioactivity

• In Vitro:
  FSEN1 (0-15 µM; H460C Cas9 cells) exhibits a synthetic lethality effect with GPX4 inhibitors and sensitizes cancer cells to ferroptosis by inhibiting FSP1.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole, FSEN 1, FSEN1, FSEN-1, Ferroptosis

Compound Identifiers

PubChem CID

22583648