Friedelin

SKU: orb1297372

Description

Friedelin is a bioactive triterpenoid studied for its multi-target pharmacological potential. Research applications include in vitro antioxidant assays and in vivo models for hepatoprotection, inflammation, and pain, supporting its investigation in pharmacology and natural product research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 559-74-0
• MW: 426.72
• Purity: 99.13%
• Formula: C₃₀H₅₀O
• SMILES: [H][C@@]12CCC(=O)[C@H](C)[C@@]1(C)CC[C@@]1([H])[C@@]2(C)CC[C@@]2(C)[C@]3([H])CC(C)(C)CC[C@]3(C)CC[C@]12C
• Target: Interleukin,Prostaglandin Receptor,NOS,NF-κB,Cytochromes P450,Caspase
• Solubility: H2O:Insoluble;DMSO:Insoluble

Bioactivity

• Target IC50:
  CYP3A4:10.79 μM (IC50)|CYP3A4:Ki: 6.16 μM|CYP2E1:18.02 μM (IC50)|CYP2E1:22.54 μM (IC50)
• In Vitro:
  In in vitro antioxidant study, the free radical scavenging effect of Friedelin on 2,2-diphenyl-picrylhydrazyl (DPPH), hydroxyl, nitric oxide and superoxide radicals were evaluated. Friedelin showed very good scavenging effect on DPPH (IC50 21.1 mM), hydroxyl (IC50 19.8 mM), nitric oxide (IC50 22.1 mM) and superoxide (IC50 21.9 mM) radicals. Friedelin also showed strong suppressive effect on lipid peroxidation. In in vivo antioxidant study, CCl4 induced oxidative stress on rats produced significant increase in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH) levels along with reduction in liver superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels. Pre-treatment of rats with Friedelin at 40 mg/kg for 7 days restored these levels to normality and showed liver protection, comparable to the standard, silymarin (25 mg/kg)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Prostaglandin Receptor, ProstaglandinReceptor, PGE, P450, CYPs, Cytochrome P450, Caspase, Inhibitor, Friedelin, inhibit, NOS

Compound Identifiers

PubChem CID

91472