FR194738 free base

SKU: orb1709672

Description

FR194738 free base

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 204067-45-8
• MW: 439.65
• Purity: 99.13% (May vary between batches)
• Formula: C₂₇H₃₇NO₂S
• SMILES: CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCC(C)(C)OCc2ccsc2)c1
• Target: Antifungal,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.51 mM);DMSO:90 mg/mL (204.71 mM)

Bioactivity

• Target IC50:
  SE (HepG2 cell homogenates):9.8 nM
• In Vivo:
  FR194738 free base reduces the serum levels of total, non high density lipoprotein and high density lipoprotein cholesterol, and triglyceride. In hamsters, FR194738 free base(32 mg/kg) increases HMG-CoA reductase activity by 1.3-fold.
  Read more...
• In Vitro:
  FR194738 free base potently inhibits squalene epoxidase in HepG2 cell homogenate and liver microsomes in dogs and rats. FR194738 free base inhibits hamster liver microsomal squalene epoxidase activity in a concentration-dependent manner with an IC50 of 14 nM. In intact HepG2 cells, FR194738 free base inhibits the incorporation of [14C]acetate into free cholesterol and cholesteryl ester in a concentration-dependent manner(IC50s = 4.9 and 8.0 nM). FR194738 free base induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FR194738, FR-194738, FR194738 free base, FR-194738 free base, FR 194738, squalene epoxidase, in HepG2 cell homogenates, Squalene epoxidase

Compound Identifiers

PubChem CID

9803248