FR-167356

SKU: orb1700558

Description

FR-167356 is a potent and selective inhibitor of the a3 isoform of vacuolar H⁺-ATPase, demonstrating activity in osteoclast, renal, and macrophage membranes. This compound has been shown to reduce bone metastasis in B16-F10 melanoma models, making it a useful research tool for studying bone biology and cancer metastasis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 174185-16-1
• MW: 378.25
• Purity: 99.74% (May vary between batches)
• Formula: C₁₉H₁₇Cl₂NO₃
• SMILES: C(C)(C)(O)C=1C=2C(=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=CC2)OC1C
• Target: Proton pump,ATPase
• Solubility: DMSO:22.5 mg/mL (59.48 mM)

Bioactivity

• In Vivo:
  In male C57BL/6 mice with B16-F10 xenografts, FR-167356 (200 mg/kg) reduces bone metastasis, inhibits tumor growth, and reduces the expression of MMP9.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FR 167356, FR167356, FR-167356, Vacuolar type H+-ATPase

Compound Identifiers

PubChem CID

10068207