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FPR2 agonist 5

SKU: orb3173553

Description

FPR2 agonist 5 is a selective agonist of formyl peptide receptor 2 (FPR2). It induces Ca2+ mobilization in HL60 cells transfected with FPR2, demonstrating an EC50 value of 1.2 μM, and causes FPR2 desensitization with an IC50 of 0.32 μM. Additionally, FPR2 agonist 5 exhibits neuroprotective effects by reducing LDH release, NO production, and the levels of IL-1β, IL-6, IL-33, and IL-10 in LPS-induced primary microglial cells from mice. It is utilized in research related to neuroinflammatory and inflammatory diseases.

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Key Properties

TargetCalcium Channel,NO Synthase,Interleukin

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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FPR2 agonist 5 (orb3173553)

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