FPL64176

SKU: orb1305812

Description

FPL64176 is a synthetic activator of L-type voltage-gated calcium channels (CaV1.x). It is utilized in cardiovascular and neuropharmacology research to study channel function and calcium signaling in both cellular assays and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 120934-96-5
• MW: 347.41
• Purity: 98.68%
• Formula: C₂₂H₂₁NO₃
• SMILES: COC(=O)c1c(C)[nH]c(C)c1C(=O)c1ccccc1Cc1ccccc1
• Target: Calcium Channel
• Solubility: DMSO:240 mg/mL (690.83 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.76 mM)

Bioactivity

• In Vivo:
  Gene expression profiling of worms harvested following in vivo FPL-64176 exposure reveals differences in transcripts associated with muscle and extracellular matrix function, as well as female reproduction, which is consistent with the worm phenotypes observed following ex vivo drug treatment.
• In Vitro:
  FPL-64176, on schistosomes cultured ex vivo and in an in vivo murine model of infection. Unlike DHPs, FPL-64176 evokes rapid and sustained contractile paralysis of adult Schistosoma mansoni reminiscent of the anthelmintic praziquantel. This is accompanied by tegument disruption and an arrest of mitotic activity in somatic stem cells and germ line tissues. Interestingly, this strong ex vivo phenotype was temperature dependent, with FPL-64176 treatment being less potent at 37 C than 23 C. However, FPL-64176 caused intra-tegument lesions at the basement membrane of worms cultured ex vivo under both conditions, as well as an in vivo hepatic shift of parasites from the mesenteric vasculature of infected mice to the liver.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ca channels, Calcium Channel, Ca2+ channels, CalciumChannel, L-type calcium channel, inhibit, FPL 64176, FPL64176, FPL-64176, Inhibitor

Compound Identifiers

PubChem CID

3423