FPH2

SKU: orb1222967

Description

FPH2 (BRD-9424) is a small molecule promoting differentiation of iPS-derived hepatocytes.

Key Properties

• CAS Number: 957485-64-2
• MW: 353.83
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₆ClN₅O₂S
• SMILES: Clc1cc(NC(=S)Nc2cn(nc2C(=O)N)CC)c(OC)cc1
• Target: p38 MAPK
• Solubility: DMSO : ≥ 125 mg/mL; 353.28 mM

Bioactivity

• In Vitro:
  FPH2 induces functional proliferation of hepatocytes in vitro, and thus may be useful for expanding mature human primary hepatocytes. FPH1 and FPH2 can increase in hepatocyte nuclei count and/or elevate the number of nuclei undergoing mitosis during primary screening, and these effects on hepatocytes are concentration dependent. Cells treated with FPH1 and FPH2 also maintain their liver-specific functions. Over 7 days, FPH2 induces hepatocyte doublings at a rate that is consistent with reported liver regeneration kinetics in vivo.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD-9424

Quick Database Links

Gene Symbol

p38 MAPK