FOXM1-IN-3

SKU: orb3210290

Description

FOXM1-IN-3 is a potent inhibitor of FOXM1 and a weak inhibitor of PI3Kγ (IC50 of 3.5 μM). It reduces FOXM1 expression at both protein and mRNA levels, inhibiting downstream effectors CCNB1 and CDC25. FOXM1-IN-3 induces G2/M phase cell cycle arrest and apoptosis in colorectal cancer cells. It also impedes colony formation and cell migration abilities of these cells. Additionally, FOXM1-IN-3 targets cancer stem cell phenotypes in colorectal cancer cells, reducing the expression of stem cell markers. It suppresses tumor growth in zebrafish xenotransplant models, making it applicable for colorectal cancer research.

Key Properties

• Target: Apoptosis,PI3K,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Apoptosis,PI3K,CDK