Fosravuconazole L-lysine ethanolate

SKU: orb1217484

Description

FosravuconazoleL-lysine ethanolate is a broad-spectrum antifungal agent. In Japan, it is approved for the treatment of onychomycosis, a fungal infection of the nail. It is a prodrug that is converted into ravuconazole.(In Vitro):Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida, Aspergillus, and Trichophyton species.(In Vivo):Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain.

Key Properties

• CAS Number: 914361-45-8
• MW: 739.7
• Purity: >98% (HPLC)
• Formula: C₃₁H₄₀F₂N₇O₈PS
• SMILES: N#CC1=CC=C(C2=CSC([C@H](C)[C@@](OCOP(O)(O)=O)(C3=CC=C(F)C=C3F)CN4N=CN=C4)=N2)C=C1.CCO.N[C@H](C(O)=O)CCCCN
• Target: Others
• Solubility: DMSO:48mg/mL (64.89mM)

Bioactivity

• In Vivo:
  Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain. Animal model: Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain). Dosage: 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg. Administration: Oral administration; daily; for 20 days. Result: Suppressed the parasitemia and prevented death.
• In Vitro:
  Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida, Aspergillus, and Trichophyton species.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS-379224 L-lysine ethanolate | E-1224 L-lysine ethanolate

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Gene Symbol

Others