Fosmidomycin sodium salt

SKU: orb1709674

Description

Fosmidomycin sodium salt is a broad-spectrum antibiotic and antimalarial agent that inhibits bacterial growth. It is widely used in research to study the non-mevalonate pathway (DXP reductoisomerase) in vitro and has shown efficacy in animal models of malaria and bacterial infection.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 66508-37-0
• MW: 205.08
• Purity: 99.43% (May vary between batches)
• Formula: C₄H₉NNaO₅P
• SMILES: O=CN(CCCP([O-])(O)=O)O.[Na+]
• Target: Antibiotic,Parasite,Antibacterial
• Solubility: H2O:20 mg/mL (97.52 mM)

Bioactivity

• In Vivo:
  After oral administration of 50 or 100 mg/kg of Fosmidomycin sodium salt, animals showed no parasites in their bodies, while treatment with 20 mg/kg resulted in a parasitemia rate of less than 1%. However, recurrence was observed when treatment was discontinued after 4 days. Complete cure was achieved in mice treated with 30 mg/kg of Fosmidomycin sodium salt 8 days.Animals apparently free of parasites are observed after intraperitoneal treatment.
• In Vitro:
  FR-31564 is a novel phosphonic acid antibiotic that exhibits activity against most Gram-negative and Gram-positive bacteria, except for mucoid Pseudomonas aeruginosa and glucose non-fermenting Gram-negative rods (excluding Pseudomonas aeruginosa)..

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FR31564, FR-31564, FR-31564 sodium salt, FR 31564, Fosmidomycin sodium, Fosmidomycin sodium salt, Antibiotic, P. falciparum

Compound Identifiers

PubChem CID

5141362