Fosifloxuridine nafalbenamide

SKU: orb1304263

Description

Fosifloxuridine nafalbenamide (NUC-3373) is a ProTide-modified nucleotide analog and thymidylate synthase inhibitor designed to overcome limitations of 5-FU. It achieves superior intracellular levels of the active metabolite FUDR-MP, demonstrating anticancer activity in preclinical in vitro and in vivo models for oncology research.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1332837-31-6
• MW: 613.53
• Purity: 95.87% (May vary between batches)
• Formula: C₂₉H₂₉FN₃O₉P
• SMILES: O(P(OC[C@H]1O[C@H](C[C@@H]1O)N2C(=O)NC(=O)C(F)=C2)(N[C@H](C(OCC3=CC=CC=C3)=O)C)=O)C=4C5=C(C=CC4)C=CC=C5
• Target: DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.52 mM);DMSO:100 mg/mL (162.99 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RNASynthesis, RNA Synthesis, Thymidylate Synthase, 5-fluorouracil, 5-fluorodeoxyuridine, 5-FU, anti-cancer, DNA Synthesis, DNASynthesis, NUC 3373, NUC3373, NUC-3373, inhibit, monophosphate, Inhibitor, FUDR, fluorodeoxyuridine, FdUMP, Fosifloxuridine nafalbenamide

Compound Identifiers

PubChem CID

53373585