Foscarnet sodium

SKU: orb1310821

Description

Foscarnet sodium is a pyrophosphate analog antiviral compound used in research for its activity against cytomegalovirus (CMV), herpesviruses, and HIV. It is applied in both in vitro and in vivo studies to investigate viral replication mechanisms and evaluate potential antiviral therapies.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 63585-09-1
• MW: 191.95
• Purity: 98.52% (May vary between batches)
• Formula: CNa₃O₅P
• SMILES: C(=O)([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+]
• Target: DNA/RNA Synthesis,Virus Protease,Reverse Transcriptase
• Solubility: H2O:3 mg/mL (15.63 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Foscarnet Sodium display an efficient therapy effect on animal with virus diseases, such as cutaneous infection, herpes keratitis, genital infection, or systemic and interacerebral infection. For example, Foscarnet Sodium (100 mM) applied at initiated 48 h post inoculation with twice daily applications of 30 μL for 4 days, displays a more than 70% reduction in cumulative score after inoculation with HSV-1 strain C42. Foscarnet Sodium (20 mg/kg) given as an aerosol to mice infected with murine CMV caused a reduction of 60% in lung titers.
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• In Vitro:
  Foscarnet Sodium is able to penetrate into cells and inhibit viral replication by inhibiting viral DNA synthesis. Foscarnet Sodium (300 μM) displays a more than 95% inhibition on HTLV-III reverse transcriptase activity in H9 cells infected with HTLV-III. Foscarnet Sodium has a low cellular toxicity, but shows an inhibition of cell proliferation at high concentrations, which is reversed after drug removal. Incubation 0.5-1 mM Foscarnet Sodium with HeLa cells or primary human lung fibroblast for 24-48 hr inhibited 50% DNA synthesis and/or cell proliferation. Foscarnet Sodium is able to bind with the heparin-binding domain of FGF2 and inhibits FGF2 induced cell proliferation. Foscarnet Sodium (25 μM) treating HUVEC cells for 48 hr reduced FGF2-induced cellular proliferation by 20%. Foscarnet Sodium (0.5-1 mM) reduced the 24h proliferation rate of CAL-62 cell, a Human thyroid anaplastic carcinoma cell line which expresses FGF2, to nearly 80%.
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• Cell Research:
  CAL-62 cells are placed on 96 well plates at 8×103 cells/well in 100 μL DMEM for 24 h. Then medium is replaced by fresh DMEM with or without foscarnet. After 48 h of incubation, 20 μL of CellTiter 96AQ solution is added to the cells and incubated for 2-4 h. The quantity of formazan product as measured by the absorbance at 492 nm.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RNA Synthesis, RNASynthesis, replication, retinitis, Reverse Transcriptase, reversible, ReverseTranscriptase, suppression, polymerase, Phosphonoformate, Phosphonoformic acid trisodium, Trisodium phosphonoformate, VirusProtease, Virus Protease, viral, antiherpesvirus, cytomegalovirus, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, DNA, inhibit, Foscarnet, Foscarnet sodium, Inhibitor

Compound Identifiers

PubChem CID

44561