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Fosaprepitant dimeglumine
Catalog Number: orb1307445
| Catalog Number | orb1307445 |
|---|---|
| Category | Small Molecules |
| Description | Fosaprepitant dimeglumine |
| CAS Number | 265121-04-8 |
| Purity | 98.75% |
| MW | 1004.83 |
| SMILES | CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C[C@@H](O[C@H]1OCCN(Cc2nn(c(=O)[nH]2)P(O)(O)=O)[C@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |
| Formula | C30H40F7N6O10P |
| Biological Activity | Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Fosaprepitant dimeglumine [orb146197]
[265121-04-8]
1004.84
C37H56F7N6O16P
1 g, 100 mg, 250 mg, 10 mM * 1 mL in DMSOFosaprepitant dimeglumine [orb1225471]
> 98%(HPLC)
265121-04-8
100 mg, 50 mg, 1 g, 500 mg, 200 mg, 25 mg, 10 mg, 5 mg
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