Forodesine hydrochloride

SKU: orb1709676

Description

Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor, with IC50 values in the sub-nanomolar range across multiple species. It suppresses lymphocyte proliferation and induces apoptosis in leukemic cells by elevating intracellular dGTP levels, making it a valuable tool for oncology and immunology research in both in vitro and in vivo models.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 284490-13-7
• MW: 302.71
• Formula: C₁₁H₁₅ClN₄O₄
• SMILES: Cl.OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1[nH]cnc2=O
• Target: Apoptosis,Nucleoside Antimetabolite/Analog,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135449327