Folinic acid calcium

SKU: orb1310893

Description

Leucovorin Calcium, the metabolically active form of folic acid, serves as a key rescue agent against folate antagonists like methotrexate. It is widely utilized in biochemical and cancer research, supporting studies on nucleotide synthesis and cellular rescue mechanisms in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1492-18-8
• MW: 511.51
• Purity: 99.30% (May vary between batches)
• Formula: C₂₀H₂₁CaN₇O₇
• SMILES: [Ca++].Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc2[nH]1
• Target: Endogenous Metabolite|||DNA/RNA Synthesis|||Antifolate
• Solubility: DMSO:Insoluble;H2O:9.8 mg/mL (19.16 mM)

Bioactivity

• Target IC50:
  zcSHMT:30 μM|zmSHMT:70 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA Synthesis, Antifolate, Calcium folinate, inhibit, Leucovorin, Leucovorin Calcium, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, Folinic acid, Folinic acid calcium, Folinic acid calcium salt, RNASynthesis, RNA Synthesis, Wellcovorin, Thymidylate synthase, VB

Compound Identifiers

PubChem CID

135403647