Foldamer 33

SKU: orb1910661

Description

Foldamer 33 is a small molecule HSP110 inhibitor, directly binds to the nucleotide-binding domain (NBD) of HSP110, blocks HSP110 chaperone function and colorectal cancer growth.Foldamer 33 significantly inhibit HSP110 anti-aggregating activity with IC50 of 87.8 uM.Foldamer 33 disrupts HSP110-STAT3 interaction with IC50 of 35.9 uM in competitive BLI assays.Foldamer 33 inhibits SW480 colorectal cancer cell proliferation, and (5 mg/kg) Foldamer 33 displays an anti-tumor effect (TGI of 40% and 60%) in mice bearing a colorectal cancer.

Key Properties

• CAS Number: 1651890-48-0
• MW: 574.677
• Purity: 0.98
• Formula: C₃₆H₃₄N₂O₅

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only