FM26

SKU: orb1709682

Description

FM26 is a potent, allosteric inverse agonist of RORγt (IC50 = 264 nM) featuring a distinct isoxazole chemotype. It effectively suppresses IL-17A mRNA in EL4 cells in vitro and serves as a valuable tool for investigating Th17 cell biology and autoimmune disease pathways in research settings.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2407981-35-3
• MW: 461.82
• Formula: C₂₂H₁₅ClF₃N₃O₃
• SMILES: C(NC1=CC=C(C(O)=O)C=C1)C=2C(=NOC2C=3C=CNC3)C4=C(C(F)(F)F)C=CC=C4Cl
• Target: ROR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145714275