FM04

SKU: orb1905849

Description

FM04 is a potent, orally bioavailable P-glycoprotein (P-gp) inhibitor with an EC50 of 83 nM. It disrupts the R262-Q1081-Q1118 pocket by interacting with Q1193 and I1115 in NBD2, uncoupling ICL2-NBD2 interactions. This inhibitor is a valuable research tool for investigating multidrug resistance in cancer models, both in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1807320-40-6
• MW: 415.48
• Purity: 99.87% (May vary between batches)
• Formula: C₂₆H₂₅NO₄
• SMILES: O=C1C=C(OC=2C1=CC=CC2)C3=CC=C(OCCOCCNCC4=CC=CC=C4)C=C3
• Target: P-gp
• Solubility: DMSO:55 mg/mL (132.38 mM)

Bioactivity

• Target IC50:
  P-gp:83 nM(EC50)
• In Vitro:
  FM04 (100 μM) exhibits competition with its photoaffinity derivative XC4 in LCC6MDR cells. FM04 inhibits P-glycoprotein with an EC50=83 nM, where the EC50 value refers to the effective modulator concentration IC50 (=3.8 nM) that reduces paclitaxel (PTX) by half in the P-gp overexpressing cell line LCC6MDR.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pgp, P-gp (P-glycoprotein)

Compound Identifiers

PubChem CID

118323802