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Catalog Number | orb1302099 |
---|---|
Category | Small Molecules |
Description | FM-381 |
CAS Number | 2226521-65-7 |
Purity | 98.27% |
MW | 428.49 |
SMILES | C(=C(C(N(C)C)=O)C#N)C=1OC(C=2N(C=3C(N2)=CNC=4C3C=CN4)C5CCCCC5)=CC1 |
Formula | C24H24N6O2 |
Biological Activity | FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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