Fluvoxamine

SKU: orb1909582

Description

Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) used as an antidepressant in research. It is applied in neuropharmacology studies to investigate serotonin signaling in both in vitro cellular assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 54739-18-3
• MW: 318.33
• Purity: 99.91% (May vary between batches)
• Formula: C₁₅H₂₁F₃N₂O₂
• SMILES: C(\CCCCOC)(=N\OCCN)/C1=CC=C(C(F)(F)F)C=C1
• Target: Serotonin Transporter,5-HT Receptor
• Solubility: DMSO:125 mg/mL (392.67 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (10.37 mM)

Bioactivity

• In Vivo:
  Fluvoxamine effectively inhibits the uptake of serotonin (5-HT) by platelets and brain synaptosomes . The antagonistic effect of fluvoxamine on reserpine-induced lowering of pentylenetetrazol (PTZ) seizure threshold can be attributed to its influence on 5-HT uptake . In contrast to desipramine and imipramine, fluvoxamine did not elicit stimulant effects in rats after administration of a rapidly acting reserpine-like compound . Fluvoxamine improves combat-related PTSD symptoms but is ineffective for depressive symptoms . Due to high dropout rates and the lack of a placebo control group, the reliability of current findings is limited, and future controlled studies on fluvoxamine for PTSD treatment are needed . When ethanol is available with food, fluvoxamine is less effective in reducing ethanol self-administration than when ethanol is available alone [ED₅₀ values were 4.0 (2.7–5.9) and 5.1 (4.3–6.0), respectively] . Under each condition where food was available, fluvoxamine had no significant effect on food intake . These results indicate that the efficacy of fluvoxamine in suppressing ethanol-maintained behavior is influenced by whether ethanol is concurrently available with food reinforcement .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fluvoxamine, DU-23000, DU23000

Compound Identifiers

PubChem CID

5324346