Fluvastatin sodium

SKU: orb1308494

Description

Fluvastatin sodium is a potent and competitive HMG-CoA reductase inhibitor used extensively in research to lower cholesterol. It is a key tool for studying lipid metabolism and atherosclerosis in both cellular (in vitro) and animal (in vivo) experimental models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 93957-55-2
• MW: 433.45
• Purity: 99.56% (May vary between batches)
• Formula: C₂₄H₂₅FNNaO₄
• SMILES: [Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c2ccccc12
• Target: Autophagy,HMG-CoA Reductase,Ferroptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.61 mM);DMSO:245 mg/mL (565.23 mM);H2O:10.8 mg/mL (24.92 mM)

Bioactivity

• Target IC50:
  HMG-CoA reductase:8 nM
• In Vivo:
  In human aortic smooth muscle cells, Fluvastatin (100 nM) reduces the formation of superoxide anion radicals activated by angiotensin II. In CHL/IU cells, Fluvastatin (8 μM) offers protection against DNA damage. It significantly inhibits the formation of thiobarbituric acid-reactive substances in lipid peroxidation initiated by divalent iron ions (IC50=12 μM). Fluvastatin (1-100 μM) can inhibit lipid peroxidation mediated by peroxyl radicals induced by 2,2'-azobis(2-amidinopropane) dihydrochloride and 2,2'-azobis.
• In Vitro:
  In a rabbit model, daily administration of Fluvastatin (10 mg/kg) significantly reversed the inhibition of acetylcholine-induced vasodilation, effectively reducing hyperlipidemia.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, pathway, Nrf2-dependent, Ferroptosis, Fluvastatin sodium, Fluvastatin sodium salt, Fluvastatin, HMG-CoA, HMGCoAReductase, HMGCR, HMGCoA Reductase, HMG-CoA reductase, XU 62-320, XU 62320 sodium, XU-62-320

Compound Identifiers

PubChem CID

23663976