Fluvastatin sodium

SKU: orb1308494

Description

Fluvastatin sodium

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 93957-55-2
• MW: 433.45
• Purity: 99.56%
• Formula: C₂₄H₂₅FNNaO₄
• SMILES: [Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c2ccccc12
• Target: HMG-CoA Reductase,Ferroptosis,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.61 mM);DMSO:245 mg/mL (565.23 mM);H2O:10.8 mg/mL (24.92 mM)

Bioactivity

• Target IC50:
  HMG-CoA reductase:8 nM
• In Vivo:
  In human aortic smooth musclee cells, Fluvastatin (100 nM) reduce the formation of superoxide anion radicals activated by angiotensin II. In CHL/IU cells, Fluvastatin (8 μM) offers protection against DNA damage. It significantly inhibit the formation of thiobarbituric acid Reactive substances in lipid peroxidation initiated by divalent iron ions IC50 12 μM). Fluvastatin (1-100 μM) can inhibit lipid peroxidation mediated by peroxyl radicals induced by 2,2'-azobis(2-amidinopropane) dihydrochloride and 2,2'-azobis.
• In Vitro:
  In a rabbit model, daily administration of Fluvastatin (10 mg/kg) significantly reverse the Inhibition of acetylcholine-induced vasodilation, effectively reducing hyperlipidemia.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Autophagy, pathway, Nrf2-dependent, Ferroptosis, Fluvastatin sodium, Fluvastatin sodium salt, Fluvastatin, HMG-CoA, HMGCoAReductase, HMGCR, HMGCoA Reductase, HMG-CoA reductase, XU 62-320, XU 62320 sodium, XU-62-320

Compound Identifiers

PubChem CID

23663976