Fluticasone furoate

SKU: orb1306375

Description

Fluticasone furoate

Research Area

Metabolism Research

Key Properties

• CAS Number: 397864-44-7
• MW: 538.58
• Purity: 99.82%
• Formula: C₂₇H₂₉F₃O₆S
• SMILES: [H][C@@]12C[C@@H](C)[C@](OC(=O)c3ccco3)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
• Target: Glucocorticoid Receptor
• Solubility: H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.13 mM);DMSO:12.5 mg/mL (23.21 mM)

Bioactivity

• Target IC50:
  Corticosteroid:0.3 nM (Kd)
• In Vivo:
  Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine. Fluticasone furonate is 99.4% bound to plasma protein in vitro Clearance of Fluticasone furonate is primarily by hydrolysis in the liver b the cytochrome P450 isozyme CYP3A4 that convert the drug to the 17β-carboxylic acid metabolite, which displays low glucocorticoid receptor agonist potenc.
• In Vitro:
  Fluticasone furoate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furoate prevents damage to cultured human lung epithelial cells by different stimul.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, lipophilic, inhibit, intranasal, fluorinated, Glucocorticoid Receptor, Fluticasone Furoate, Fluticasone furoate, GlucocorticoidReceptor, Allermist, allergic, Anti-inflamatory, anti-asthmatic, Avamys, corticosteroid, CYP3A4, rhinitis, Veramyst

Compound Identifiers

PubChem CID

9854489